Autophagic activity in neuronal cell death

Autophagic Cell Death and Cancer

Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies ...

Autophagic Cell Death and Cancer Chemotherapeutics

Autophagy usually functions in cell-protective events. However, it may also be utilized as a cell-suicide mechanism, which is known as “autophagic cell death.” Autophagic cell death is frequently induced in cells that lack apoptotic machinery, such as p53-defi cient cancer cells. Therefore, small compounds that activate autophagic cell death are good candidates for anticancer chemotherapeutics ...

Autophagic cell death during Drosophila embryogenesis

Autophagic activity in all cardiovascular cell types

Introduction Cardiovascular disease is the leading cause of mortality throughout the developed world (1). Research identifying novel risk factors, innovative diagnostic modalities, and therapeutic interventions, coupled with education of clinicians and patients, have led to dramatic improvements in age-adjusted cardiovascular death rates (2). Nevertheless, changes in lifestylerelated factors an...

Neuronal Cell Death

penheim, 1991; Burek and Oppenheim, 1998). Although Neurons may die at many different developmental stages some of these hypotheses have received experimental and for many different reasons. As in other tissues, difsupport in individual systems, none seems to be generferent stimuli produce quite different morphological ally applicable. Indeed, it remains to be demonstrated that manifestations o...